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Surgery is usually the last resort and is typically considered in older patients or those with significant under-eye bags, rather than someone who only has mild dark circles

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According to the Journal of Biomaterials Science , controlled studies on aged skin have shown that the tripeptide may reduce the appearance of fine lines and wrinkles

Future preclinical work may probe combinations with incretin-based agents or -oxidation enhancers to define mechanistic complementarity

Longer exposure, combined with full-dose maintenance after titration, produces substantially deeper weight loss

Determining the clinical and long-term effects of these biochemical findings will be of great interest