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Increased proinflammatory cytokine secretion (such as IL6, CXCL8), reduced cell viability, increased oxidative stress, morphologic alteration of secretory functions, and alteration of barrier function on exposure to both high doses of non-nicotinized and nicotinized ECIG-liquid have been reported 16,59,60

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Moreover, the greater surface-to-mass ratio of ultrafine particles and PM can further increase the contacts with cells and enhance the damages, which may eventually lead to hemorrhagic events in blood vessels 43

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