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In a 2020 review, the researchers corroborated that silymarin's capacity to reduce oxidative stress on the liver could indeed improve biomarkers associated with conditions such as alcoholic fatty liver disease, nonalcoholic fatty liver disease, alcoholic cirrhosis, and drug-induced liver injury.29 Although the studies covered in the review used 420mg silymarin doses, others have found that amounts as low as 200mg could also impart the desired effects on liver health.30 If that weren't all, a 2018 study concluded that silymarin may actually increase glutathione levels in the liver.31 Selenium (55mcg) Selenium is an essential mineral with antioxidant properties, and one that may increase levels of an enzyme called glutathione peroxidase (GPx).32 GPx is important because it uses reduced glutathione to neutralize hydrogen peroxide,33 one of the major ROS

56 In especially severe cases, a regular exchange transfusion regimen can be considered to reduce bilirubin levels and alleviate icterus, although this approach was not uniformly agreed upon by all members of the working group

Mitochondria and aging-the role of exercise as a countermeasure

The connection between chronic, complex illnesses like Long COVID and the collapse of detoxification pathways is a rapidly emerging area of medical research

Prez-Taboada I, Alberquilla S, Martn ED, Anand R, Vietti-Michelina S, Tebeka NN, et al

19) (Enroth et al