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J Physiol Paris 94:105110 Sikiric P, Seiwerth S, Grabarevic Z et al (2001a) Cysteamine-colon and cysteamine-duodenum lesions in rats

The model predicts that initial knock-down of Keap1 by siKEAP1 is counteracted by increasing Nrf2 concentrations, which subsequently upregulate Keap1 and Srxn1 mRNA production (Fig 3C)

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Specific alterations in the expression of the urea cycle enzymes in different cancers profoundly affect nitrogen-containing macromolecules, such as nucleotides and proteins, which are associated with tumor initiation and progression, even immunotherapy response (Lee et al., 2018)

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