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NLRP3 inhibitor MCC950 lessened myocardial infarct size in mice and reduced inflammatory cell infiltration

PubMed, doi:10.1038/sj.bjc.6603880

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Similarly, in myocardial ischemia-reperfusion, 3-AB suppressed PARP1 activation, reduced infarct size, and improved cardiac function 174

In addition, urinary concentration and total urinary loss of 2-hydroxyestrogen was found to be 10 times higher in healthy subjects compared to RA [11]