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During acute attacks, treatments focus on pain management, often with strong pain relievers, and symptom relief with medications like antiemetics and sedatives

In 2019, the research team led by Zhao Yingming introduced the concept of lactylation, a groundbreaking revelation that highlighted lactates significant role in modulating histone lysine residue modifications [16]

ROS reactive oxygen species NAC N-acetylcysteine omega 3 fatty acids, vitamin C and sulforaphane have also been studied in those with this disorder targeting oxidative stress via different mechanisms of action with mixed results (Bent et al., 2014

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Furthermore, cell labeling with Zombie Red, a fluorescent marker of cells with permeable cell membrane related to cell death induction, confirmed that glutathione did not altered cell integrity even at high concentrations (Figure 2B)