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Mitochondrial GSTs are also known as kappa class GSTs and are soluble enzymes which bear structural similarities with cytosolic GSTs

The study characterized the degradation kinetics of AOD9604 in biological matrices and identified the specific cleavage products generated by endogenous proteases

However, our study has several limitations

Yilmaz M, Ravandi F, Loghavi S, Wang S, Borthakur G, Dinardo C, Kadia T, Kanagal-Shammanna R, Pemmaraju N, Oran B, Popat U, Pierce S, Jabbour E, Short N, Issa G, Ohanian M, Garcia-Manero G, Andreeff M , Patel K, Konopleva M, Kantarjian H, Daver N

d) Nitric oxide (NO) release which triggers cGMP pathways

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