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Cisplatin detoxification by GSH generally occurs by a reaction catalyzed by GST, in which GSH binds covalently to cisplatin and the formed GSH conjugates can be exported from the cells, preventing the drug from reaching its most important molecular target, DNA

It is composed of three amino acidsglutamine, cysteine, and glycine

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As a nation, we still have significant strides to make and milestones to reach to eradicate HCV

doi: 10.1371/journal.pone.0023881 175 LoLHHuangTLShieaJ

The inactivation of GPX4 can be achieved through both indirect approaches, including GSH depletion, as well as direct methods involving pharmacological or genetic interventions