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Intestinal inflammation and compromised epithelial barrier integrity accelerate the systemic dissemination of bacterially derived uremic toxins such as IS, PCS, and TMAO, which induce oxidative stress and cause progressive renal damage

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The Th2 cytokines also downregulate loricrin and involucrin, two additional barrier proteins that normally create a sealed, protective envelope around skin cells

however, VW in these groups was markedly lower than in group HLG ( P 0.05), but was remarkably higher in contrast with group CON ( P 0.05), and both were notably lower than in groups HL and CON ( P 0.05)