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10.3390/biom10050697 Summary Keywords mitochondrial respiration, persulfide, polysulfide, protein persulfide, reactive sulfur species, selective inhibitor, sulfide oxidation, transsulfuration pathway Citation Hirabayashi K, Sasaki E, Ohno H, Takayama O, Yamada S and Hanaoka K (2026) Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors