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The purification of pancreatic stellate cells using Nycodenz is almost exclusively carried out according to the methods for hepatic cells [4,5] and was first described by Apte et al [16]

doi: 10.1186/s40478-020-00956-z

Interestingly, cell adhesion to extracellular matrix also plays an important role in cellular metabolism: detachment from ECM inhibits glucose metabolism and mitochondrial respiration, leading to reduced energy synthesis within cells and increased intracellular ROS production (125)

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Selumetinib and docetaxel combination treatment significantly increased response rates for KRASmutant NSCLC as compared with when docetaxel (NCT01933932) is used alone (NCT01933932) [314]

[250] Some patients may experience temporary sleep disruption when discontinuing long-term melatonin use, particularly if underlying sleep disorders have not been addressed