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Hu, R., Han, C., Pei, S., Yin, M

Apoptosis in CD is regulated via both intrinsic (e.g., Bcl-2 family, mitochondrial ROS/JNK) and extrinsic (e.g., TNF-/TNFR) pathways, with network-like dysregulation involving molecules like Runx2, VPS4B, circSMAD4, and MPST

Abbreviations AD: Alzheimer disease A: Amyloid beta CI: Confidence interval DSM: Diagnostic and Statistical Manual of Mental Disorders DTBN: 5,5-Dithio-bis(2-nitrobenzoic acid) GSH: Glutathione HC: Healthy control MCI: Mild cognitive impairment MEGA-PRESS: Meshcher-Garwood Point-Resolved Spectroscopy MMSE: Mini-Mental State Examination MRS: Magnetic resonance spectroscopy OPA: O-Phthalaldehyde OS: Oxidative stress PRESS: Point resolved spectroscopy SMD: Standardized mean difference STEAM: STimulated Echo Acquisition Mode References Koyama A, O'Brien J, Weuve J, Blacker D, Metti AL, Yaffe K

Folic Acid (400 mcg) & Vitamin D (5 g) Folic acid is important for DNA synthesis and proper cell division, essential before pregnancy occurs

Epperly MW, Kagan VE, Sikora CA, Gretton JE, Defilippi SJ, Bar-Sagi D, et al

However, when they are prolonged without resolution, potentially irreversible disease states can arise