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In 2013, the company announced the successful completion of the first in-human clinical trial of a stapled peptide drug (ALRN-5281) for the treatment of rare endocrine diseases such as adult growth hormone deficiency and HIV lipodystrophy

In 2015, administration of Setmelanotide to obese individuals for a limited time increased resting energy expenditure (REE) by 6.4% and shifted substrate oxidation to fat (29)

PubMed 18068698 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al

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Peptides promote fat loss by suppressing appetite and stimulating lipolysis, the breakdown of stored fat

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