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The lean-user math uses class analogy from semaglutide and tirzepatide PK literature, not direct retatrutide measurement

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The increase of the expression of MMP2 and MMP7 in the colon indicated that the EpCAM +/ mice are more sensitive to colitis than WT mice, and the elevation of the levels of MMP2, MMP7, MMP8 and MMP12 further confirmed that the DSS administration induced the severer inflammation in the colon of EpCAM +/ mice than the WT mice

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