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[DOI] [PubMed] [Google Scholar] 25.Bhatia P., Kulkarni J.D., Pai S.A

Prospective randomized trials of lowering homocysteine levels with supplements of folic acid, vitamin B 12 , and vitamin B 6 against placebo over a 5-year period in patients with vascular disease or diabetes have not, however, shown a reduction of first event fatal or nonfatal myocardial infarction, nor have these supplements reduced the risk of recurrent cardiovascular disease after an acute myocardial infarct

One such compound, chrysophanol, extracted from Rheum palmatum , has been shown to improve memory, learning, and social interaction in ASD mice through the downregulation of the mTOR pathway [133]

The JAX mouse nomenclature committee designated the lines B6.Cg- Hgf Tm1.1Tbf (MGI:6294040, founder line with neo cassette) and B6.Cg- Hgf Tm1Tbf (MGI:6294042, neo cassette removed), referred to here as Hgf del10Neo and Hgf del10 , respectively