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Navone, S

Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans

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The glucose metabolic reprogramming in CRC centers on the EMP-TCA cycle nexus, glucose uptake is facilitated initiated by glucose transporter 1 (GLUT1)-mediated glucose influx [13]

On the contrary, MTX + carnitine samples (group 6) showed significant protective efficacy on renal parenchyma with almost intact kidney corpuscles (star), mild focal records of tubular epithelial damage (red arrow) alternated with obvious integral tubular segments (black arrow) and minimal interstitial infiltrates