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The side effect profiles differ slightly between the two medications

This has created a complex and evolving regulatory environment

Moreover, treatment of CC mice with NA rescued NAD + levels in skeletal muscle, improved muscle function, and increased Oxphos complexes expression, yet NA treatment had no effect on mitochondrial respiration 248

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Numerous studies have shown that all four vitamin B12 forms are converted to the same intermediate form in the cells and during this process, ligands of the specific supplemented vitamin B12 form cyano, hydroxy, adenosyl or methyl are removed (Obeid et al., 2015