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However, the levels of cyanide resulting from cyanocobalamin are so minimal that the term toxic is hardly applicable here Build up in the cells: studies have shown that around 1000 g of cyanocobalamin accumulates in the cell fluid during therapy with high dosages (2)

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It's more invasive, certainly, potentially leading to discomfort, site reactions, and requires specific training for proper administration

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Bisubstrate strategies to target methyltransferases

However, this complexity makes peptide synthesis more challenging and costly