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Compounds 34 and 35 (Figure 25) were found to be the most effective inhibitors of P38 kinase, with IC 50 values of 47 nM and 45 nM, respectively

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Dihexa is reported to be active at picomolar concentrations in synaptogenesis assaysapproximately 10,00010,000,000-fold more potent than BDNF (brain-derived neurotrophic factor) in some in vitro measures, though this comparison involves different assay conditions and should not be taken as a direct clinical equivalence claim