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By regulating mitochondrial TML availability, SLC25A45 links environmental stressors such as cold exposure and fasting to adaptive fuel switching toward fatty acid oxidation, thereby optimizing mitochondrial energetics and metabolic resilience

doi: 10.5498/wjp.v11.i8.412

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The study design was rigorous

This study also found that hypoxia-inducible factor 1-alpha (HIF-1) levels were not uniform throughout the retinal layers and controlled hypoxia of the entire circulatory system may result in more uniform levels and possibly positive effects on disease progression, as seen in Leigh Syndrome (Jain et al., 2016)