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As one of the important mediators of RA, it can induce angiogenesis, promote FLSs migration and cartilage destruction, and inhibit the apoptosis of synovial cells (211)

doi: 10.1016/00166480(91)90301L 158 HallTRHarveySChadwickA

The resulting lack of IDO2 activity hinders tryptophan conversion to kynurenine

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