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Additionally, the KD-fed mice showed elevated blood ketone levels and preserved motor neurons in the lumbar spinal cord, indicating improved motor neuron survival [40]

In vitro studies have indicated that the activation of HDAC1 and HDAC3 induces microglial phenotypic transformation and exacerbates neuroinflammation, whereas defects promote the development of anti-inflammatory microglia (Lisek et al

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Berberine can cross the placenta and may affect newborns, which is why it is not recommended in these groups

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