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Since then, several other agents targeting genome instability have been approved for clinical use, including platinum-based cisplatin [11], topoisomerase inhibitors such as camptothecin and anthracyclines [12], and Poly(ADP-ribose) polymerase (PARP) inhibitors such as olaparib [13]

10.1186/1471-2180-11-231 15 CortesT.SchubertO

- Skin is noticeably whiter in one week

Concentrations of ACT were optimized to impair to the same extent as in HEK293 treated with 15 M ACT (loss of 40% growth)

elegans has served as a highly illuminating model for the elaboration of fundamental mechanisms of aging and proteostasis

In addition, simultaneous recording on pairs of GPi cells also showed a high degree of discharge synchronization (63)