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10.1242/jcs.073874 83 KimJ.-Y.JoJ.LeemJ.ParkK.-K

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doi: 10.1046/j.1365-2265.1997.2601068.x

MSM is a naturally occurring sulfur compound that plays a vital role in joint health and reducing inflammation, while glutathione is often referred to as the body's "master antioxidant," crucial for detoxification and immune function

Phellodendrin has been shown to inhibit HIF-1-regulated macrophage PI3K/Akt and glycolysis, restoring the M1/M2 macrophage balance in periodontitis, thereby reducing the pro-inflammatory effects and immune dysfunction caused by overactivated M1 macrophages (92)