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Although the benefits of aspirin in patients with CAD and carotid artery disease have been demonstrated by large-scale clinical trials, 90,91 several recent studies have questioned the efficacy of aspirin in patients with PAD

Smoking More than half of all long-term smokers will develop COPD (Mannino 2007

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JAMA Network Open, 1 (6), e183337

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This has limited insights into potential functional differences between canonical AREs and those that emerge with increasing disease aggressiveness