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In patients with hepatic encephalopathy, the impaired reaction of cerebral oxyhemoglobin concentration might occur due to astrocyte swelling and dysfunction 42,43,44 because some reports showed that astrocyte controls the regional cerebral blood flow and provides energy sources such as ketone body and carnitine to the neuron 39,41

Age-related metabolite profiles and their relation to clinical outcomes in young adults, middle-aged individuals, and older people

If carnitine levels in the body are low, such as when on a low carb diet, fat is not efficiently burned during workouts, and the rate of fat loss is diminished

High levels of these reduced cofactors signal that the electron transport chain is fully engaged, leading to a downregulation of MCAD activity and slowing fatty acid oxidation when the cell's energy needs are met

Cuando este sistema no funciona bien (por falta de carnitina o por disfuncin metablica), puede aumentar la dependencia de la glucosa, acumularse intermediarios lipdicos y empeorar la eficiencia energtica

J Biol Chem 2000;275:40064-72 16 -Wagner CA ea