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Sulfur index analysis (sulfur metabolomics) Sulfur index analysis was carried out using S -bimanyl derivatives through LC MS/MS (Shimadzu Nexera UHPLC system with on-line LCMS 8040, Kyoto, Japan), as previously described 59,60,61,62

[76] Defective DNA repair has been linked to neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, ataxia telangiectasia, Cockayne syndrome, Parkinson's disease and xeroderma pigmentosum