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The neuroprotective action of IHT might be associated with generation of reactive oxygen species which in turn activate an extensive defense program, including nuclear factor erythroid 2-related factor 2 (Nrf2)a transcriptional factor regulating expression of genes encoding numerous phase II defense enzymes that collectively afford powerful antioxidant and anti-inflammatory cytoprotection (Dringen et al., 2015)

This shell shields the active core from acids and enables direct fusion with cellular membranes, delivering nutrients directly into the bloodstream

Furthermore, to evaluate apoptosis induction, the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay was performed using the in situ cell death detection kit

Larger-scale trials were less common: 31 trials planned to recruit over 200 participants, including three exceeding 1000

This compound plays a crucial role in helping the body's natural defense system protect the health of the cells from oxidative stress caused by free radicals

This role of GSH is clearly illustrated by a rapid oxidation of GSH when H 2 O 2 is applicated to neurons [53]