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Achrol AS, Rennert RC, Anders C, Soffietti R, Ahluwalia MS, Nayak L, et al

95 Other metabolites produced by the liver, such as lysophosphatidylcholine (LPC), are quickly converted to lysophosphatidic acid (LPA) in the bloodstream, which then alters brain neuronal activity and appetite regulation

This disruption occurs through several molecular pathways, including alterations in glutamatergic signaling and changes in receptor expression (Gerace et al