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Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma

Important Considerations for Combining NAD+ and AOD9604 Despite the theoretical appeal, several crucial points must be considered when exploring the combination of NAD+ and AOD9604: Lack of Direct Combined Research: The most significant caveat is the current lack of extensive human clinical trials specifically investigating the combined effects of NAD+ precursors and AOD9604

Contraindications : Individuals with a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should avoid these injections

J Biol Chem 272:1911519124

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This is an unusual mechanism of drug interactions, since usually displacement from albumin will expose more drug to be metabolized (leading to re-equilibration)