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Notably, cells can develop resistance to GPX4 inhibition, and multiple GPX4-independent ferroptosis pathways have been identified

A randomized, double-blind phase I/IIa study of intranasal glutathione in Parkinson's disease

These factors should be carefully considered when selecting compounds for nanoparticle development [151]

Senescent CAFs, which develop a senescence-associated secretory phenotype, express elevated levels of immunoregulatory genes and can create a strongly immunosuppressive niche

Chapman MR, Robinson LS, Pinkner JS, Roth R, Heuser J, Hammar M, et al

Consequently, what part LOX plays in ferroptosis is open to question and requires further investigation