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There is evidence that butyrate is involved in the metabolism of -cells in the pancreatic islets due to its interaction with G-protein coupled receptors (GPR) like free fatty acid receptors FFAR3 (GPR41) and FFAR2 (GPR43), as seen in Figure 1 (64, 68, 69)

In addition, SARS-CoV-2 infection leads to the release of pro-angiogenic factors, such as vascular endothelial growth factor A (VEGF-A) (103)