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Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene

The FBXO22BACH1 study may explain part of the endothelial response, but it does not yet explain every earlier finding involving VEGFR2, Src, eNOS, FAK, or ERK1/2

It could also be due to the adipocyte dysfunction linked to low vitamin B12 levels through cellular inflammation

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