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Thus, therapeutic strategies designed to improve the recovery from exhaustion, such as combination checkpoint blockade (e.g., anti-PD-1 plus anti-LAG-3) or the development of novel bispecific CAR-T cells targeting PD-L1 and other coexpressed receptors, are fundamentally based on this principle [238,239,240]

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This could be due to: Disruption of normal cellular processes that depend on proper folate metabolism Alterations in DNA methylation patterns, which can affect gene expression Increased oxidative stress due to elevated homocysteine levels Symptoms Of MTHFR Mutations Scientists are still researching the possible symptoms of MTHFR gene mutations