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LBE supplementation led to an increase in indole derivatives, metabolites produced by the GI microbiota from dietary tryptophan and known to have immunological significance, as observed in untargeted metabolomics

During metabolic stresses such as increased oxidative phosphorylation or changes in cytoplasmic homeostasis that induce ER stress, the UPS will be compromised, which would most likely result in a reduction in BACE1 degradation by the UPS and lysosomes

Collectively, these results indicate that hippocampal astrocytic Hb, rather than CA1 pyramidal neuronal Hb, is necessary for the antioxidative action of KDS12025, effectively alleviating astrogliosis and hippocampus-dependent memory impairment in an animal model of AD

10.1002/jimd.12009 24 GiovinazzoD.BursacB.SbodioJ

Therefore, the administration of H.pylori eradication therapy (which remove H.pylori as a source of ROS) or the micronutrient antioxidants, (vitamin E and/or thioctic acid) may play a basic role in replenishing the depleted micronutrients thus, enhancing ROS removal and decreasing MDA level

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