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Such disturbances have been described in ASD brain tissue and support the relevance of methyl-donor pathways in ASD biology [32,33,34]

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These included amyotrophic lateral sclerosis (ALS), pulmonary fibrosis (PF), acute respiratory distress syndrome (ARDS), Duchenne muscular dystrophy (DMD), cystic fibrosis (CF), Huntingtons disease (HD), pulmonary hypertension (PH), cytokine release syndrome (CRS), frontotemporal dementia (FTD), and graft-versus-host disease (GVHD)., All selected diseases were confirmed to be classified as rare diseases by Orphanet ( a widely used global database for rare diseases

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Transcriptional change in a cultured cell line is a hypothesis-generating observation