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Patients are not candidates for laser liposuction if they are pregnant or breastfeeding, have insulin-dependent diabetes, have active or chronic liver disease or hepatitis, have coronary artery disease, unstable hypertension, bleeding disorders, or are on Coumadin/Heparin

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However, the incidence and mortality rates related to cancer are increasing every day worldwide [15]

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As a tumor suppressor, Parkin directly binds to PHGDH and catalyzes its ubiquitination at lysine 330, leading to proteasomal degradation

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