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Given that GMSCs are of a neural crest origin [18, 35, 36], our previous studies have shown that ex vivo expanded GMSCs could directly convert to NCSC-like or neural progenitor-like cells under defined culture conditions, which exerted better therapeutic effects on axonal regeneration and functional recovery of injured peripheral nerves than their parental GMSC counterparts [34, 41]

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The glycosaminoglycan (GAG, a proteoglycan side chain) content decreases and catabolic matrix metalloproteinase (MMP) activity and denatured collagen content increases - the latter creating a more rigid IVD matrix reviewed in [2, 5, 6]