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Interestingly, the induction of MAFbx/Atrogin-1 and MuRF1 was suppressed in TRAF6 null mice, suggesting that TRAF6 is an upstream regulator of these E3 ubiquitin ligases

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hyperemia/hemorrhage was graded from focal to diffuse according to lamina propria or subendothelial localisation

Disclosures: Mohammad AbuAssi: Nothing to Disclose, Dara Suleiman: Nothing to Disclose, Saqr Alsakarneh: Nothing to Disclose, Farah Khraisat: Nothing to Disclose, Talib Al-Abcha: Nothing to Disclose, Harsimran Kalsi: Nothing to Disclose, Tony Brar: Nothing to Disclose, Yaseen Perbtani: Nothing to Disclose 1304 HIGH-THROUGHPUT PROTEOMICS ANALYSIS IDENTIFIES CHANGES IN CIRCULATING PROTEOME SIGNATURES ACROSS DIFFERENT STAGES OF LIVER TRANSPLANTATION SURGERY Xing Li 1 Emily Bethea 1 Leigh Anne Dageforde 1 Katherine Specht 1 Russell Goodman 1 , 1 Massachusetts General Hospital Background: Circulating proteomics, the unbiased global analysis of quantitative protein expression, has been applied to identify the diagnostic and pathophysiologic signatures of various liver diseases such as ALD, MASLD and HCC