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N -(5-(((5-( tert -butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)thio)acetyl)piperidine-4-carboxamide ( 7 )

This underscores the need to cap duration at the high end of dosing and de-escalate once symptoms abate

The depletion of ER Ca 2+ promotes the formation of mitochondrial-associated ER membrane, leading to mitochondrial Ca 2+ overload and dysfunction

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