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Dosage decisions should be made in consultation with qualified research oversight, and human application requires appropriate institutional review

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Systemic effects from topical application are rare but not impossible with very high concentrations or compromised skin barriers

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How long the injection lasts depends on several factors: How severe the deficiency is A persons age and how fast their body processes things Problems with digestion or absorbing nutrients Daily habits or activity levels How often does the body use B12 inside its cells People with pernicious anemia or ongoing deficiency often get weekly shots, while others do fine with a monthly injection