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Neuregulin-1 (NRG-1), produced by cardiac microvascular EC, acts upon ErbB2 and ErbB4 receptors in adult CM with context-dependent effects (Parodi and Kuhn, 2014)

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Certain blood disorders and cancers: Myeloproliferative disorders and some malignancies can raise B12 due to excess binding proteins

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Interestingly, inhibition of different enzymes in the TCA cycle results in different regulation of amino acid metabolism, although common features are evident (Ryan et al., 2021)