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Moreover, the affinity of Acs1 for acetate is reported to be several times greater than that of the constitutively expressed Acs2 isoform, suggesting that Acs1 is primarily responsible for acetyl-CoA synthesis during growth on non-fermentable carbon sources such as ethanol 26

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Thus, EV-bound EBV-miR-BART13-3p in circulation is a promising, NPC-selective, biomarker that should be considered as part of a screening strategy to identify NPC in endemic regions