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Notably, overexpression of P53 gene is known to play a key role in reducing oxidative stress levels by, for instance, mediating enzyme activity of known ROS scavengers glutathione peroxidase (GPX) and aldehyde dehydrogenase (ALDH) [233]

pmid:13584877 42

Second, N-hydroxy-L-arginine is oxidized to L-citrulline and NO with the aid of L-arginine and co-factor BH 4 (Fig

Activated SMAD2/3 complexes with SMAD4 are translocated into the nucleus, where they modulate gene transcription linked to proliferation, differentiation, apoptosis, and immune regulation