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Connexin mutants compromise the lens circulation and cause cataracts through biomineralization

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An evidence base for novel targets and both pharmacological and non-pharmacological treatments is beginning to emerge and has been recognised recently in publications by the American Society of Clinical Oncology and analgesic trial design expert groups such as ACTTION

Where deficiency is confirmed, treatment may include oral supplementation (for dietary insufficiency or mild malabsorption) or intramuscular hydroxocobalamin injections (for pernicious anaemia or severe malabsorption), as per NICE and British Society for Haematology guidelines

Maleimide and terephthalic acid are commonly used in plastic synthesis and may appear due to pervasive microplastic contaminants

On a titration curve, the pK a can be observed as the point of inflection near the center of the plateau. The inflection point is where the curvature changes from concave up to concave down