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Hyperpigmentation at libido-range doses (0.51.5mg, 23x/week) without UV exposure is uncommon but not impossible in subjects with high baseline melanocyte density

[1] [3] The unique aspect of this formulation lies in its high concentration and the option for preservative-free preparation, which may be suitable for patients with sensitivities or allergies to common preservatives

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However, a small number of patients may display abnormalities durin1g brain magnetic resonance imaging (MRI), such as left frontal encephalomalacia, cerebral atrophy, porencephalic cysts, and left frontal brain cysts [18]

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The recent Childrens Oncology Group (COG) ARST0332 trial (which included MPNSTs) utilized the AJCC sixth edition staging system, which was current at the time of study inception