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It also raises the risk of vitamin B12 deficiency

"Association of biochemical B 1 2 deficiency with metformin therapy and vitamin B 1 2 supplements: the National Health and Nutrition Examination Survey, 19992006"

In conclusion, we describe a novel additive effect on vitamin B 12 deficiency risk for metformin exposure with a previously reported genetic risk factor in the cubilin receptor gene

Methionine and inositol support liver health and the nervous system

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The other patient had a low haptoglobin level