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First, under conditions of nutritional ketosis, -HB constitutes the principal KB in systemic circulation, representing the majority of the dynamic range in circulating ketone concentrations

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Conversely, other members of the Firmicutes phylum, such as Clostridium and Enterococcus , are typically found in lower abundances in microbiota influenced predominantly by diets rich in plant-based foods (78, 79)

We tested whether the RNAi-mediated disruption of the DMP in animals would lead to increases in GSSG production and a redox imbalance, and we observed no increase in GSSG disruption of DMP in the JV2 roGFP-sensor strain (Supplementary Fig