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However, due to poor intrinsic sensitivity of NMR and the need to accumulate each NMR spectrum for ~4 min, the glyoxalase reactions appeared to be too fast to study in intact cells and tissues (going to completion in 10,000 times in liquid-state NMR

Justicia, C., Ramos-Cabrer, P

Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region

Hanauer et al

Although some of these controversies are clearly based on methodological problems and plain misinterpretation of the data, more recent studies demonstrate that multiple signaling mechanisms dependent on the experimental conditions in animals or specific circumstances in patients, can lead to different modes of APAP-induced cell death, which is the topic of this critical review, which is based on our extensive experience with this topic and the pertinent literature

Kirby, A