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Step-up Therapy & Maintenance Phase Some patients require higher doses of the medication to achieve optimal results

Poor Blood Circulation Reduced circulation, often due to stress, lack of sleep, or smoking, can limit oxygen and nutrient supply to the skin, making it appear tired and lacklustre

BDNF signaling also has antidepressant potential in chronic unpredictable mild stress

People react differently to treatments due to differing brain chemistry and severity of the disease

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Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine